Invitrogen™ alpha-1 Antitrypsin Polyclonal Antibody

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
PIPA5118939	Invitrogen™ PA5118939	200 μL
PIPA5122246	Invitrogen™ PA5122246	20 μL

Description

alpha-1 Antitrypsin Polyclonal Antibody for Western Blot, IHC (P)

Alpha-1-AT is synthesized in the liver and it acts as an inhibitor of proteases such as trypsin, elastase, chymotrypsin, collagenase, leucocytic proteases, plasmin, and thrombin, which may be released during inflammatory reactions in the lung. In the absence of alpha-1-AT, these enzymes are not inhibited and they may digest pulmonary parenchyma. Alpha-1-AT deficiency is associated with chronic obstructive lung disease (emphysema) and less frequently with hepatic cirrhosis in infants and respiratory distress of the newborn. Increase in alpha-1-AT occurs as an acute phase response to tissue necrosis and inflammation. Serum level of alpha-1-AT is elevated in rheumatoid arthritis, bacterial infections, vasculitis, and carcinomatosis.

Specifications

• Antigen: alpha-1 Antitrypsin
• Content And Storage: -20°C
• Classification: Polyclonal
• Form: Liquid
• Isotype: IgG
• Target Species: Mouse
• Gene: Serpina1a
• Gene Alias: a-1 AT; A1A; a1-antitrypsin; A1AT; AAT; Aat2; Aat-2; alpha 1 antitrypsin; alpha-1 antitrypsin; alpha-1 protease inhibitor; Alpha-1 protease inhibitor 1; alpha-1-antiproteinase; Alpha-1-antitrypsin; alpha-1-antitrypsin (protease inhibitor); alpha-1-antitrypsin 1-1; alpha-1-antitrypsin 2; alpha-1-antitrypsin null; alpha1AT; alpha-1-protease inhibitor; alpha-1-proteinase inhibitor; Digestive Zymogen; Dom1; MGC23330; MGC9222; PI; PI1; PRO0684; PRO2209; PRO2275; protease inhibitor 1 (anti-elastase), alpha-1-antitrypsin; protease inhibitor 1 (anti-elastase, antitrypsin, alpha-1); Protease Serine 1; serine (or cysteine) peptidase inhibitor, clade A, member 1A; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1; serine (or cysteine) proteinase inhibitor, clade A (alpha-1antiproteinase, antitrypsin), member 1; serine (or cysteine) proteinase inhibitor, clade A, member 1; serine (or cysteine) proteinase inhibitor, clade A, member 1a; Serine Protease 1; serine protease inhibitor 1-1; Serine protease inhibitor A1a; serine protease inhibitor alpha 1; serine proteinase inhibitor, clade A, member 1; serpin A1; Serpin A1a; serpin family A member 1; serpin peptidase inhibitor clade A member 1; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1; SERPINA1; Serpina1a; Short peptide from AAT; SPAAT; Spi1; Spi1-1; Spi1-3; TRP1; TRY1
• Gene Symbols: Serpina1a
• Primary or Secondary: Primary
• Purification Method: Antigen affinity chromatography

• Concentration: 0.5 mg/mL
• Applications: Immunohistochemistry (Paraffin), Western Blot, Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300
• Gene Accession No.: P07758
• Gene ID (Entrez): 20700
• Immunogen: Recombinant protein Alpha-1-Antitrypsin. The antigen corresponds to amino acid range 25-413 of the target protein.
• Product Type: Antibody