Invitrogen™ alpha-1b Adrenergic Receptor Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA532660

Catalog No. PIPA532660

Description

Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Monkey, Marmoset (95%); Mouse, Hamster, Elephant (85%). For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

The alpha-1b adrenoceptor is an Adrenergic Receptor that causes contraction of smooth muscle cells and thereby controls vascular tone, blood pressure, and accelerates the development of atherosclerosis. Decreased alpha-1b adrenoceptor is associated with benign prostatic hyperplasia (BPH). This adrenergic receptor also acts as a proto-oncogene when transfected into cell lines where constitutive activation of the receptor induces neoplastic transformation. The alpha-1b adrenoceptor has been documented in adrenal, aorta, blood, various brain regions, eye, heart, kidney, liver, prostate, spinal cord, and spleen. ESTs have been isolated from kidney (normal and cancer) and lung carcinoma libraries.

Specifications

• Antigen: alpha-1b Adrenergic Receptor
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Adra1b
• Gene Alias: [a]1b; ADA1B; ADRA1; ADRA1B; Adrenergic alpha 1B- receptor; adrenergic receptor, alpha 1b; adrenergic, alpha-1B-, receptor; adrenoceptor alpha 1B; alpha 1B-adrenoceptor; alpha 1B-adrenoreceptor; alpha-1B adrenergic receptor; Alpha-1B adrenoceptor; alpha-1B adrenoreceptor; alpha-1B-adrenergic receptor; alpha1B-adrenergic receptor; ALPHA1BAR
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 147
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin)
• Concentration: 1 mg/mL
• Formulation: PBS with 0.1% sodium azide
• Gene Accession No.: P35368
• Gene Symbols: Adra1b
• Immunogen: Synthetic 20 amino acid peptide from C-terminal cytoplasmic domain of human ADRA1B.
• Quantity: 50 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov