Alpha-2-macroglobulin Mouse anti-Human, Clone: 4B11F7, Proteintech

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-173-6562	Proteintech Group Inc 661261IG150UL	150 μL

Description

Alpha 2-Macroglobulin (a2M), is a approximately 720-kDa homotetrameric glycoprotein composed of four identical approximately 180 kDa subunits. aAlpha 2M shares with other alpha-macroglobulins, like the complement components C3 and C4 and the pregcy zone protein PZP, an extraordinary binding capacity for a variety of ligands. This allows the alpha-macroglobulins to serve as humoral defense barriers against foreign peptides in the plasma. Alpha 2M interacts and captures virtually any proteinase, often referred to as a panprotease inhibitor. In the brain of Alzheimer′s disease (AD) patients, Alpha 2M also has been localized to diffuse amyloid plaques, supporting an important role for alpha 2M in AD etiopathology.

Specifications

• Antigen: Alpha-2-macroglobulin
• Concentration: 1.8 mg/mL
• Classification: Monoclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: A2M, Alpha 2 M, alpha 2 macroglobulin, CPAMD5, FWP007, S863 7, alpha-2M
• Gene Symbols: A2M
• Isotype: IgG2a
• Purification Method: Protein A
• Product Type: Antibody

• Clone: 4B11F7
• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Conjugate: Unconjugated
• Host Species: Mouse
• Target Species: Human
• Gene Accession No.: P01023
• Gene ID (Entrez): 2
• Immunogen: Alpha-2-macroglobulin Fusion Protein Ag19245
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: A2M