Invitrogen™ alpha-2a Adrenergic Receptor Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA1048

Catalog No. PA1048

Description

PA1-048 detects alpha-2A adrenergic receptor (A2AAR) from human, rat and mouse tissues. PA1-048 has been successfully used in Western blot and immunohistochemistry procedures. By Western blot, this antibody detects an ~45 kDa protein representing A2AAR from mouse kidney membrane preparations. The PA1-048 immunogen is a synthetic peptide corressponding to residues R(218) I Y Q I A K R R T R V P P S R R G(235) of the 3rd intracellular loop of human A2AAR. This sequence is completely conserved between human, mouse, rat, and porcine A2AAR.

Alpha-2-adrenergic receptors (ADRA2A) are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. ADRA2A mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G protein. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system.

Specifications

• Antigen: alpha-2a Adrenergic Receptor
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Adra2a
• Gene Alias: ADRA2; Adra-2; ADRA2A; Adra-2a; ADRA2R; ADRAR; adrenergic receptor, alpha 2a; adrenergic, alpha-2A-, receptor; adrenoceptor alpha 2A; alpha(2A)AR; alpha-2 adrenergic receptor subtype C10; alpha2A; alpha-2A adrenergic receptor; Alpha-2A adrenoceptor; alpha-2A adrenoreceptor; alpha2A-adrenergic receptor; ALPHA2AAR; alpha-2AAR; alpha2A-AR; alpha-2AAR subtype C10; alpha-2-adrenergic receptor, platelet type; alpha2-C10; alpha-2D adrenergic receptor; AW122659; CA2-47; OTTHUMP00000058849; RATRG20; RG20; subtype alpha2-C10; ZNF32
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11551, 150, 25083
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.6 mg/mL
• Formulation: PBS with 1 mg/mL BSA and 0.05% sodium azide
• Gene Accession No.: P08913, P22909, Q01338
• Gene Symbols: Adra2a
• Immunogen: Synthetic peptide corressponding to residues R(218) I Y Q I A K R R T R V P P S R R G(235) of the 3rd intracellular loop of human A2AAR.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG