alpha-2c Adrenergic Receptor Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA527166

Catalog No. PIPA527166

Description

Recommended positive controls: HeLa, HepG2. Predicted reactivity: Mouse (100%), Rat (100%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences.

Specifications

• Antigen: alpha-2c Adrenergic Receptor
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ADRA2C
• Gene Alias: [a]2C; Adra 2c; ADRA2C; Adra-2c; ADRA2L2; ADRA2RL2; ADRARL2; Adrenergic alpha2C- receptor class I; adrenergic receptor, alpha 2c; adrenergic, alpha-2C-, receptor; Adrenergic, alpha2C-, receptor class I; adrenoceptor alpha 2C; Alpha 2CAR; alpha-2 adrenergic receptor subtype C4; alpha2 AR C4; alpha2 C4; alpha2-AR-C4; alpha2C; Alpha-2C adrenergic receptor; alpha-2C adrenoceptor; Alpha-2C adrenoreceptor; alpha2-C4; alpha-2C-adrenergic receptor; ALPHA2CAR; alpha-2CAR; Alpha-2C-AR; subtype alpha2-C4
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 152
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.62 mg/mL
• Formulation: 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: P18825
• Gene Symbols: ADRA2C
• Immunogen: Synthetic peptide corresponding to a region within amino acids 318 and 409 of Human alpha 2c Adrenergic Receptor
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov