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alpha-2c Adrenergic Receptor Polyclonal Antibody, Invitrogen™

Catalog No. PIPA527166
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100 μL
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PIPA527166 100 μL
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Catalog No. PIPA527166 Supplier Thermo Scientific Supplier No. PA527166

Description

Rabbit Polyclonal Antibody

Recommended positive controls: HeLa, HepG2. Predicted reactivity: Mouse (100%), Rat (100%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences.
TRUSTED_SUSTAINABILITY

Specifications

Antigen alpha-2c Adrenergic Receptor
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.62 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
Gene ADRA2C
Gene Accession No. P18825
Gene Alias [a]2C; Adra 2c; ADRA2C; Adra-2c; ADRA2L2; ADRA2RL2; ADRARL2; Adrenergic alpha2C- receptor class I; adrenergic receptor, alpha 2c; adrenergic, alpha-2C-, receptor; Adrenergic, alpha2C-, receptor class I; adrenoceptor alpha 2C; Alpha 2CAR; alpha-2 adrenergic receptor subtype C4; alpha2 AR C4; alpha2 C4; alpha2-AR-C4; alpha2C; Alpha-2C adrenergic receptor; alpha-2C adrenoceptor; Alpha-2C adrenoreceptor; alpha2-C4; alpha-2C-adrenergic receptor; ALPHA2CAR; alpha-2CAR; Alpha-2C-AR; subtype alpha2-C4
Gene Symbols ADRA2C
Host Species Rabbit
Immunogen Synthetic peptide corresponding to a region within amino acids 318 and 409 of Human alpha 2c Adrenergic Receptor
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 152
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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