Invitrogen™ alpha Actinin 1 Polyclonal Antibody

Catalog No.	Quantity
PIPA582233	100 μL

Catalog No. PIPA582233 Supplier Invitrogen™ Supplier No. PA582233

Description

Rabbit Polyclonal Antibody

Immunogen sequence: SAKEGLLLWC QRKTAPYKNV NIQNFHISWK DGLGFCALIH RHRPELIDYG KLRKDDPLTN LNTAFDVAEK YLDIPKMLDA EDIVGTARPD EKAIMTYVSS FYHAFSGAQK AETAANRICK V Highest antigen sequence indentity to the following orthologs: Mouse - 98%, Rat - 99%.

Alpha Actinin 1 belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: alpha Actinin 1
• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 0.05 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: ACTN1
• Gene Accession No.: P12814, Q7TPR4, Q9Z1P2
• Gene Alias: 3110023F10Rik; actinin; actinin 1 smooth muscle; actinin alpha 1; actinin, alpha 1; Actn1; Actn1a; alpha actinin 1a; alpha-actinin; alpha-actinin cytoskeletal isoform; Alpha-actinin-1; BDPLT15; F-actin cross-linking protein; fibroblast alpha actinin; FLJ40884; FLJ54432; hypothetical protein; hypothetical protein LOC524770; I79_004057; non-muscle alpha-actinin 1; non-muscle alpha-actinin-1
• Gene Symbols: ACTN1
• Host Species: Rabbit
• Immunogen: Recombinant protein corresponding to Human ACTN1. Recombinant protein control fragment (Product #RP-88918).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 109711, 81634, 87
• Target Species: Human, Mouse, Rat
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG