Invitrogen™ alpha Actinin 2/3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA599425

Catalog No. PIPA599425

Description

Antibody detects endogenous levels of total Actinin alpha 2/3.

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles.

Specifications

• Antigen: alpha Actinin 2/3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ACTN2
• Gene Alias: 1110008F24Rik; actinin alpha 2; actinin alpha 3; actinin alpha 3 (gene/pseudogene); Actinin alpha3; actinin, alpha 2; actinin, alpha 3; Actinin-alpha3; ACTN2; ACTN3; alpha-actinin skeletal muscle; Alpha-actinin skeletal muscle isoform 2; Alpha-actinin skeletal muscle isoform 3; Alpha-actinin-2; alpha-Actinin3; alpha-actinin-3; alphaActinin-3; CMD1AA; CMH23; F-actin cross-linking protein
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11472, 11474, 171009, 291245, 88, 89
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: O88990, P35609, Q08043, Q9JI91
• Gene Symbols: ACTN2, ACTN3
• Immunogen: A synthesized peptide derived from human ACTN2(Accession P35609), corresponding to amino acid residues K38-D88.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG