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Invitrogen™ alpha Actinin 2 Monoclonal Antibody (EA-53)
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Catalog No. PIMA549311
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100 μg
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Catalog No. Quantity
PIMA549311 100 μg
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Catalog No. PIMA549311 Supplier Invitrogen™ Supplier No. MA549311
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Mouse Monoclonal Antibody

Adding 1 mL of PBS buffer will yield a concentration of 100 μg/mL. Positive Control - WB: rat cardiac muscle tissue, rat skeletal muscle tissue, mouse cardiac muscle tissue, mouse skeletal muscle tissue, human placenta tissue. IHC: human mammary cancer tissue, mouse lung tissue. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it i involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments.
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Specifications

Antigen alpha Actinin 2
Applications Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone EA-53
Concentration 100 μg/mL
Conjugate Unconjugated
Formulation Ascites, 1.2% sodium acetate with 2mg BSA and 0.01mg sodium azide
Gene Actn2
Gene Accession No. P35609, Q9JI91
Gene Alias 1110008F24Rik; actinin alpha 2; actinin, alpha 2; ACTN2; alpha-actinin skeletal muscle; Alpha-actinin skeletal muscle isoform 2; Alpha-actinin-2; CMD1AA; CMH23; F-actin cross-linking protein
Gene Symbols Actn2
Host Species Mouse
Immunogen Rabbit skeletal alpha-actinin.
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100350274, 11472, 291245, 88
Target Species Human, Mouse, Rabbit, Rat
Content And Storage -20°C
Product Type Antibody
Form Lyophilized
Isotype IgG1
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