Invitrogen™ alpha Actinin 4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5118929

Catalog No. PIPA5118929

Description

alpha Actinin 4 Polyclonal Antibody for Western Blot, IHC (P)

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis.

Specifications

• Antigen: alpha Actinin 4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Actn4
• Gene Alias: actinin alpha 4; ACTININ-4; actinin-Alpha-4; Actn4; alpha actinin 4; alpha-actinin-4; C77391; F-actin cross-linking protein; focal segmental glomerulosclerosis 1; FSGS; FSGS1; non-muscle alpha-actinin 4
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography, Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 100517284, 81
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.4
• Gene Accession No.: O43707
• Gene Symbols: Actn4
• Immunogen: Recombinant protein Actinin Alpha 4. The antigen corresponds to amino acid range 1-269 of the target protein.
• Quantity: 200 μL
• Primary or Secondary: Primary
• Target Species: Human, Pig
• Product Type: Antibody
• Isotype: IgG