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Invitrogen™ alpha Actinin 4 Polyclonal Antibody
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Catalog No. 421400
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Catalog No. Quantity
42-140-0 100 μg
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Catalog No. 42-140-0 Supplier Invitrogen™ Supplier No. 421400
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Description

Rabbit Polyclonal Antibody

alpha Actinin 4 Polyclonal Antibody for Western Blot, IHC, ICC/IF

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen alpha Actinin 4
Applications Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.25 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% sodium azide; pH 7.4
Gene Actn4
Gene Accession No. O43707, P57780, Q9QXQ0
Gene Alias actinin alpha 4; ACTININ-4; actinin-Alpha-4; Actn4; alpha actinin 4; alpha-actinin-4; C77391; F-actin cross-linking protein; focal segmental glomerulosclerosis 1; FSGS; FSGS1; non-muscle alpha-actinin 4
Gene Symbols Actn4
Host Species Rabbit
Immunogen Synthetic peptide derived from the N-terminal region of the human, mouse, and orangutan alpha-Actinin-4 protein.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 60595, 63836, 81
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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