Invitrogen™ alpha Adducin Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA529641

Catalog No. PIPA529641

Description

Recommended positive controls: Jurkat, Raji, NCI-H929, mouse liver. Predicted reactivity: Mouse (98%), Rat (98%), Zebrafish (89%), Xenopus laevis (93%), Chicken (98%), Rhesus Monkey (100%), Bovine (99%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described.

Specifications

• Antigen: alpha Adducin
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ADD1
• Gene Alias: Add1; ADD2; ADDA; ADDB; adducin 1; adducin 1 (alpha); Adducin beta; Adducin1; Adducin-1; Adducin-alpha; Adducin-beta; AI256389; Alpha adducin; alpha-ADD; alpha-adducin; beta Adducin; Beta-adducin; erythrocyte adducin alpha subunit; erythrocyte adducin subunit alpha
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11518, 118
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.96 mg/mL
• Formulation: 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: P35611, Q9QYC0
• Gene Symbols: ADD1
• Immunogen: Recombinant protein encompassing a sequence within the center region of human alpha Adducin. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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