Invitrogen™ alpha/beta Tubulin Monoclonal Antibody (TU-10), Alexa Fluor™ 488

Catalog No.	Quantity
PIMA544130	100 μg

Catalog No. PIMA544130 Supplier Invitrogen™ Supplier No. MA544130

Description

Mouse Monoclonal Antibody

This antibody recognizes alpha, beta-tubulin heterodimer, a basic intracellular structural unit of microtubules. Alpha- and beta-tubulins form approximately 100 kDa tubulin heterodimer, a globular protein that polymerizes to form microtubules.

Tubulin protein is the major constituent of microtubules. Tubulin is a dimer of alpha and beta chains, which binds two molecules of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. There are at least six isotypes of both alpha- and beta- tubulin in human cells, which are distinguished by slightly different amino acid sequences and encoded by a large, multigene family that has been highly conserved throughout evolution. Although the most important functions of microtubules in proliferative cells are through their actions as components of the mitotic spindle, they are also involved in many other essential functions throughout the cell cycle of both malignant and nonmalignant cells. Anti-microtubule agents including Vinca alkaloids and taxanes may disrupt many of these essential functions.

Specifications

• Antigen: alpha/beta Tubulin
• Applications: Flow Cytometry, Western Blot, Immunocytochemistry
• Classification: Monoclonal
• Clone: TU-10
• Concentration: 0.1 mg/mL
• Conjugate: Alexa Fluor 488
• Formulation: TBS with 0.2% BSA and 15mM sodium azide
• Gene: TUBB
• Gene Accession No.: A2AQ07, P02550, P07437, P68369, P68370, Q71U36, Q767L7, Q9H4B7
• Gene Alias: 2810484G07Rik; Alpha-tubulin 1; Alpha-tubulin 3; Alpha-tubulin isotype M-alpha-1; B-ALPHA-1; beta 5-tubulin; beta Ib tubulin; CDCBM6; CSCSC1; Detyrosinated tubulin alpha-1A chain; FLJ30169; H2 ALPHA; hum-a-tub1; hum-a-tub2; LIS3; M(beta)1; M40; OK/SW-cl.56; Talpha1 alpha-tubulin; Tuba1; Tuba-1; TUBA1A; TUBA3; TUBB; TUBB1; TUBB2A; TUBB5; Tubulin alpha; tubulin alpha 1a; tubulin alpha 3; tubulin alpha-1 chain; Tubulin alpha-1A chain; tubulin alpha-3 chain; Tubulin B-alpha-1; tubulin beta; tubulin beta 1 class VI; tubulin beta chain; tubulin beta class I; tubulin beta-1 chain; Tubulin beta-5 chain; tubulin, alpha 1; tubulin, alpha 1A; tubulin, alpha, brain-specific; tubulin, beta 1 class VI; tubulin, beta 2A class IIa; tubulin, beta class I; tubulin, beta family 1; tubulin, beta polypeptide; a/ß-tubulin
• Gene Symbols: TUBA1A, TUBB, TUBB1
• Host Species: Mouse
• Immunogen: Microtubule proteins from porcine brain (aa 1-444).
• Purification Method: Size-exclusion chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 100134983, 100135051, 203068, 22142, 545486, 64158, 679312, 733686, 7846, 81027
• Target Species: Human, Mouse, Rat, Monkey, Pig
• Content And Storage: 4°C, store in dark, DO NOT FREEZE!
• Product Type: Antibody
• Form: Liquid
• Isotype: IgM