Invitrogen™ alpha/beta Tubulin Monoclonal Antibody (TU-10), Alexa Fluor™ 488

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA544130

Catalog No. PIMA544130

Description

This antibody recognizes alpha, beta-tubulin heterodimer, a basic intracellular structural unit of microtubules. Alpha- and beta-tubulins form approximately 100 kDa tubulin heterodimer, a globular protein that polymerizes to form microtubules.

Tubulin protein is the major constituent of microtubules. Tubulin is a dimer of alpha and beta chains, which binds two molecules of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. There are at least six isotypes of both alpha- and beta- tubulin in human cells, which are distinguished by slightly different amino acid sequences and encoded by a large, multigene family that has been highly conserved throughout evolution. Although the most important functions of microtubules in proliferative cells are through their actions as components of the mitotic spindle, they are also involved in many other essential functions throughout the cell cycle of both malignant and nonmalignant cells. Anti-microtubule agents including Vinca alkaloids and taxanes may disrupt many of these essential functions.

Specifications

• Antigen: alpha/beta Tubulin
• Classification: Monoclonal
• Concentration: 0.1 mg/mL
• Formulation: TBS with 0.2% BSA and 15mM sodium azide
• Gene Accession No.: A2AQ07, P02550, P07437, P68369, P68370, Q71U36, Q767L7, Q9H4B7
• Gene Symbols: TUBA1A, TUBB, TUBB1
• Immunogen: Microtubule proteins from porcine brain (aa 1-444).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat, Monkey, Pig
• Product Type: Antibody
• Isotype: IgM

• Applications: Flow Cytometry, Western Blot, Immunocytochemistry
• Clone: TU-10
• Conjugate: Alexa Fluor 488
• Gene: TUBB
• Gene Alias: 2810484G07Rik; Alpha-tubulin 1; Alpha-tubulin 3; Alpha-tubulin isotype M-alpha-1; B-ALPHA-1; beta 5-tubulin; beta Ib tubulin; CDCBM6; CSCSC1; Detyrosinated tubulin alpha-1A chain; FLJ30169; H2 ALPHA; hum-a-tub1; hum-a-tub2; LIS3; M(beta)1; M40; OK/SW-cl.56; Talpha1 alpha-tubulin; Tuba1; Tuba-1; TUBA1A; TUBA3; TUBB; TUBB1; TUBB2A; TUBB5; Tubulin alpha; tubulin alpha 1a; tubulin alpha 3; tubulin alpha-1 chain; Tubulin alpha-1A chain; tubulin alpha-3 chain; Tubulin B-alpha-1; tubulin beta; tubulin beta 1 class VI; tubulin beta chain; tubulin beta class I; tubulin beta-1 chain; Tubulin beta-5 chain; tubulin, alpha 1; tubulin, alpha 1A; tubulin, alpha, brain-specific; tubulin, beta 1 class VI; tubulin, beta 2A class IIa; tubulin, beta class I; tubulin, beta family 1; tubulin, beta polypeptide; a/ß-tubulin
• Host Species: Mouse
• Purification Method: Size-exclusion chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 100134983, 100135051, 203068, 22142, 545486, 64158, 679312, 733686, 7846, 81027
• Content And Storage: 4°C, store in dark, DO NOT FREEZE!
• Form: Liquid