Invitrogen™ alpha Catenin Monoclonal Antibody (1G5)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA12000

Catalog No. MA1-2000

Description

MA1-2000 detects alpha catenin from human samples. MA1-2000 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~102 kDa protein representing alpha catenin from scc-1 cell extract. In Western blot, this antibody did not cross-react with mouse samples. MA1-2000 can also be used in immunoprecipitation and immunofluorescence procedures. The MA1-2000 immunogen is a 90 kDa MBP/alpha catenin fusion protein purified via an amylose column.

Alpha catenin is a member of the b-catenin family of cytosolic proteins. Alpha catenin interacts with N-cadherin and b-catenin on the cytosolic side of adherins junctions to mediate the interaction with the actin cytoskeleton. Alpha catenin is a homodimer in solution, but dissociates to form a 1:1 heterodimer with b-catenin in order to interact with cadherins. It also regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Alpha catenin also functions in the control of the startle modulation.

Specifications

• Antigen: alpha Catenin
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1mg/mL BSA and 0.05% sodium azide
• Gene Accession No.: P26232, P35221
• Gene Symbols: CTNNA1, CTNNA2
• Immunogen: 90 kDa MBP/alpha catenin fusion protein purified on amylose column.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunoprecipitation, Western Blot, Immunocytochemistry
• Clone: 1G5
• Conjugate: Unconjugated
• Gene: CTNNA2
• Gene Alias: 102 kDa cadherin-associated protein; 2010010M04Rik; AA517462; AI481747; AI988031; alpha E catenin; alpha E-catenin; Alpha N-catenin; alpha(E)-catenin; alpha(N)-catenin; alpha-catenin; alpha-catenin-related protein; alpha-E-catenin; alphaE-catenin; alpha-N-catenin; alphaN-catenin; cadherin associated protein; Cadherin-associated protein; cadherin-associated protein, related; cancer/testis antigen 114; CAP102; CAPR; CAP-R; catenin; catenin (cadherin associated protein), alpha 1; catenin (cadherin associated protein), alpha 2; catenin (cadherin-associated protein), alpha 1, 102kDa; catenin (cadherin-associated protein), alpha 2; catenin alpha 1; catenin alpha 2; Catenin alpha1; catenin alpha-1; Catenin alpha2; Catenin alpha-2; catenin, alpha 1; Catenin-alpha1; Catenin-alpha2; Catna; Catna1; Catna2; cdf; cerebellar deficient folia; chp; CT114; CTNNA1; Ctnna2; CTNR; FLJ36832; FLJ52416; HGNC:2509; MDPT2; Neural alpha-catenin; NY-REN-13 antigen; renal carcinoma antigen NY-REN-13
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 1495, 1496
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov