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  6. Invitrogen™ alpha GalCer:CD1d Complex Monoclonal Antibody (L363), PE, eBioscience™, Invitrogen™ 

Invitrogen™ alpha GalCer:CD1d Complex Monoclonal Antibody (L363), PE, eBioscience™, Invitrogen™

Catalog No. 5010714
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50-107-14 25 μg
50-107-15 100 μg
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Catalog No. 50-107-14 Supplier Invitrogen™ Supplier No. 12201980
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Description

Mouse Monoclonal Antibody

Description: This L363 monoclonal antibody reacts with alpha-galactosylceramide bound to the mouse MHC class I-like protein CD1d. This complex is recognized by invariant natural killer T (iNKT) cells, a subset of T lymphocytes that expresses the invariant TCR alpha chain Valpha14Jalpha18. Activation of iNKT cells leads to production of Th1 and Th2-associated cytokines as well as dendritic cell maturation. The L363 antibody has been reported to neutralize iNKT cell activation by alpha-galactosylceramide:CD1d complexes. Applications Reported: This L363 antibody has been reported for use in flow cytometric analysis. Applications Tested: This L363 antibody has been tested by flow cytometric analysis of alpha-galactosylceramide-loaded mouse CD1d-transfected cells. This can be used at less than or equal to 0.25 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser. Filtration: 0.2 μm post-manufacturing filtered.

This complex is recognized by invariant natural killer T (iNKT) cells, a subset of T lymphocytes that expresses the invariant TCR alpha chain Va14Ja18. Activation of iNKT cells leads to production of Th1 and Th2-associated cytokines as well as dendritic cell maturation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen alpha GalCer:CD1d Complex
Applications Flow Cytometry
Classification Monoclonal
Clone L363
Concentration 0.2 mg/mL
Conjugate PE
Formulation PBS with 0.09% sodium azide; pH 7.2
Gene Cd1d1
Gene Accession No. P11609, Q9JHE4
Gene Alias 3'-phosphoadenosine-5'-phosphosulfate:Galcer sulfotransferase; 3'-phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase; 3'-phosphoadenylylsulfate-galactosylceramide 3'-sulfotransferase; AI747460; Antigen-presenting glycoprotein CD1d1; CD1.1; Cd1a; Cd1d; CD1d.1; Cd1d1; CD1d1 antigen; cerebroside sulfotransferase; Cst; Gal3st1; galactose-3-O-sulfotransferase 1; galactosylceramide sulfotransferase; GalCer sulfotransferase; Gcst; Ly-38; T-cell surface glycoprotein CD1d1
Gene Symbols Cd1d1, Gal3st1
Host Species Mouse
Purification Method Affinity chromatography
Quantity 25 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12479, 53897
Target Species Mouse
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG2a κ
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