Invitrogen™ alpha-II Spectrin Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA587363

Catalog No. PIPA587363

Description

Immunogen sequence: REQAQSCRQQ VAPTDDETGK ELVLALYDYQ EKSPREVTMK KGDILTLLNS TNKDWWKVEV NDRQGFVPAA YVKKLDPAQS ASRENLLEEQ GSIALRQEQI DNQTRITKEA GSVSLRMKQV EELYHSLLEL GEKRKGMLEK SCKKFMLFRE ANELQQWINE KEAALTSEEV GADLEQVEVL Q; Positive Samples: U-87MG, Jurkat, A-549, NIH/3T3, Mouse kidney, Rat spinal cord; Cellular Location: Cytoplasm, cell cortex, cytoskeleton.

SPTAN1 (spectrin alpha chain, non-erythrocytic 1) is a part of the spectrin family of filamentous cytoskeletal proteins. They function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. SPTAN1 has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in this gene are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants.

Specifications

• Antigen: alpha-II Spectrin
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SPTAN1
• Gene Alias: (ALPHA)II-SPECTRIN; 2610027H02Rik; A2a; a--fodrin; alpha; alpha II spectrin; alpha-fodrin; alpha-II spectrin; alpha-spectrin; alpha-spectrin 2; alpha-spectrin 2, brain; brain; brain alpha-spectrin; EIEE5; FLJ44613; Fodrin alpha chain; inhibitory protein factor; IPF; NEAS; noerythroid alpha-spectrin 2; Non erythrocytic spectrin alpha; non-erythrocytic 1 (alpha-fodrin); non-erythroid alpha chain; nonerythroid alpha-spectrin; nonerythroid alpha-spectrin 2; putative alpha-spectrin; SPECA; Spectrin; Spectrin alpha; spectrin alpha chain; Spectrin alpha chain brain; spectrin alpha chain, brain; spectrin alpha chain, non-erythrocytic 1; spectrin alpha, non-erythrocytic 1; spectrin, alpha, non-erythrocytic 1; spectrin, alpha, non-erythrocytic 1 (alpha-fodrin); spectrin, non-erythroid alpha chain; spectrin, non-erythroid alpha subunit; Spna2; Spna-2; Spta2; Sptan1
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 20740, 64159, 6709
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 2.04 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: P16086, P16546, Q13813
• Gene Symbols: SPTAN1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 950-1130 of human Alpha Fodrin (NP_0011239101).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG