Invitrogen™ alpha Internexin Monoclonal Antibody (1D2)

Catalog No.	Quantity
PIMA14709	100 μL

Catalog No. PIMA14709 Supplier Invitrogen™ Supplier No. MA14709

Description

Mouse Monoclonal Antibody

In Western blot, a band at ~66 kDa is detected. The epitope recognized by MA1-4709 (C-terminal non-helical extension of the protein) is unusually resistant to aldehyde fixation, so formalin fixation of histological sections is recommended.

alpha-Internexin is a Class IV intermediate filament subunit expressed very early in neuronal development. It is related to but distinct from the better known neurofilament triplet proteins, NF-L, NF-M and NF-H, having similar protein sequence motifs and a similar intron organization. Many classes of mature neurons contain a-internexin in addition to NF-L, NF-M and NF-H. In some mature neurons a-internexin is the only neurofilament subunit expressed. Antibodies to internexin are therefore unique probes to study and classify neuronal types and follow their processes in sections and in tissue culture. In addition the very early developmental expression of a-internexin means its presence is an early and convenient diagnostic feature of neuronal progenitors cells and other cell committed to the neuronal lineage. The use of antibodies to this protein in the study of brain tumors has not been examined to date, but is likely to be of interest.

Specifications

• Antigen: alpha Internexin
• Applications: Immunohistochemistry, Western Blot, Immunocytochemistry
• Classification: Monoclonal
• Clone: 1D2
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 10mM sodium azide
• Gene: INA
• Gene Accession No.: P23565, P46660, Q16352
• Gene Alias: 66 kDa neurofilament protein; Alpha-internexin; alpha-Inx; AV028420; FLJ18662; FLJ57501; Ina; Inexa; internexin neuronal intermediate filament protein alpha; internexin neuronal intermediate filament protein, alpha; internexin, alpha; Intlaa; LOW QUALITY PROTEIN: alpha-internexin; MGC12702; NEF5; Neuro; Neurofilament 5; neurofilament 5 (66kD); Neurofilament 66; neurofilament-66; neurofilament-66, tax-binding protein; Nf66; NF-66; TXBP-1
• Gene Symbols: INA
• Host Species: Mouse
• Immunogen: Recombinant rat alpha-internexin expressed in and purified from E. coli.
• Purification Method: Protein G
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 226180, 24503, 9118
• Target Species: Human, Mouse, Rat, Multi-species
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1