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Invitrogen™ alpha Internexin Polyclonal Antibody

Catalog No. PIPA14737
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100 μL
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PIPA14737 100 μL
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Catalog No. PIPA14737 Supplier Invitrogen™ Supplier No. PA14737
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Description

Chicken Polyclonal Antibody

In Western blot, a band at ~66 kDa is detected. Minor bands of approximately 50 kDa and 150 kDa are also detected, which most likely correspond to alpha-internexin breakdown products and covalent dimers, respectively.

alpha-Internexin is a Class IV intermediate filament subunit expressed very early in neuronal development. It is related to but distinct from the better known neurofilament triplet proteins, NF-L, NF-M and NF-H, having similar protein sequence motifs and a similar intron organization. Many classes of mature neurons contain a-internexin in addition to NF-L, NF-M and NF-H. In some mature neurons a-internexin is the only neurofilament subunit expressed. Antibodies to internexin are therefore unique probes to study and classify neuronal types and follow their processes in sections and in tissue culture. In addition the very early developmental expression of a-internexin means its presence is an early and convenient diagnostic feature of neuronal progenitors cells and other cell committed to the neuronal lineage. The use of antibodies to this protein in the study of brain tumors has not been examined to date, but is likely to be of interest.
TRUSTED_SUSTAINABILITY

Specifications

Antigen alpha Internexin
Applications Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 15 mg/mL
Conjugate Unconjugated
Formulation PBS with 10mM sodium azide
Gene INA
Gene Accession No. P23565, P46660, Q08DH7, Q16352
Gene Alias 66 kDa neurofilament protein; Alpha-internexin; alpha-Inx; AV028420; FLJ18662; FLJ57501; Ina; Inexa; internexin neuronal intermediate filament protein alpha; internexin neuronal intermediate filament protein, alpha; internexin, alpha; Intlaa; LOW QUALITY PROTEIN: alpha-internexin; MGC12702; NEF5; Neuro; Neurofilament 5; neurofilament 5 (66kD); Neurofilament 66; neurofilament-66; neurofilament-66, tax-binding protein; Nf66; NF-66; TXBP-1
Gene Symbols INA
Host Species Chicken
Immunogen Recombinant rat alpha-internexin expressed in and purified from E. coli.
Purification Method IgY fraction
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 226180, 24503, 532236, 9118
Target Species Human, Mouse, Rat, Bovine
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgY
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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