Invitrogen™ Alpha Sarcoglycan Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA552450

Catalog No. PIPA552450

Description

Immunogen sequence: SALDRGGRVP LPIEGRKEGV YIKVGSASPF STCLKMVASP DSHARCAQGQ PPLLSCYDTL APHFRVDWCN VTLVDKSVPE PADEVPTPGD GILEHDPFFC PPTEAPDRDF LVD Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 94%.

The sarcoglycan transmembrane proteins are members of the dystrophin complex. Sarcoglycans cluster together to form a complex, which is localized in the cell membrane of skeletal, cardiac, and smooth muscle fibers. Four sarcoglycan subunit proteins, designated alpha-, beta-, gamma- and delta-sarcoglycan, form a complex on the skeletal muscle cell surface membrane. A genetic defect in any one of these proteins causes the loss or marked decrease of the whole sarcoglycan complex, which is observed in the autosomal recessive muscular dystrophy, sarcoglycanopathy. In smooth muscle, beta- and delta-sarcoglycans are associated with epsilon-sarcoglycan, a glycoprotein homologous to alpha-sarcoglycan. Additionally, a complete deficiency in delta-sarcoglycan is the cause of the Syrian hamster BIO.14 cardiomyopathy.

Specifications

• Antigen: Alpha Sarcoglycan
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SGCA
• Gene Alias: 50 kDa dystrophin-associated glycoprotein; 50DAG; 50kD DAG; adhalin; ADL; Alpha-sarcoglycan; alpha-SG; Asg; DAG2; DMDA2; Dystroglycan 2; Dystroglycan2; dystroglycan-2; LGMD2D; limb girdle muscular dystrophy 2D; sarcoglycan alpha; sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein); sarcoglycan, alpha (dystrophin-associated glycoprotein); SCARMD1; SG alpha; SG-alpha; Sgca
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 6442
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q16586
• Gene Symbols: SGCA
• Immunogen: Recombinant protein corresponding to Human SGCA. Recombinant protein control fragment (Product #RP-90085).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG