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Invitrogen™ Alpha Sarcoglycan Polyclonal Antibody
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Catalog No. PIPA5106600
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100 μL
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PIPA5106600 100 μL
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Catalog No. PIPA5106600 Supplier Invitrogen™ Supplier No. PA5106600
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total SGCA.

The sarcoglycan transmembrane proteins are members of the dystrophin complex. Sarcoglycans cluster together to form a complex, which is localized in the cell membrane of skeletal, cardiac, and smooth muscle fibers. Four sarcoglycan subunit proteins, designated alpha-, beta-, gamma- and delta-sarcoglycan, form a complex on the skeletal muscle cell surface membrane. A genetic defect in any one of these proteins causes the loss or marked decrease of the whole sarcoglycan complex, which is observed in the autosomal recessive muscular dystrophy, sarcoglycanopathy. In smooth muscle, beta- and delta-sarcoglycans are associated with epsilon-sarcoglycan, a glycoprotein homologous to alpha-sarcoglycan. Additionally, a complete deficiency in delta-sarcoglycan is the cause of the Syrian hamster BIO.14 cardiomyopathy.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Alpha Sarcoglycan
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene SGCA
Gene Accession No. P82350, Q16586
Gene Alias 50 kDa dystrophin-associated glycoprotein; 50DAG; 50kD DAG; adhalin; ADL; Alpha-sarcoglycan; alpha-SG; Asg; DAG2; DMDA2; Dystroglycan 2; Dystroglycan2; dystroglycan-2; LGMD2D; limb girdle muscular dystrophy 2D; sarcoglycan alpha; sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein); sarcoglycan, alpha (dystrophin-associated glycoprotein); SCARMD1; SG alpha; SG-alpha; Sgca
Gene Symbols SGCA
Host Species Rabbit
Immunogen A synthesized peptide derived from human SGCA(Accession Q16586), corresponding to amino acid residues P167-D217.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 20391, 303468, 6442
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

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