Invitrogen™ alpha Synuclein Polyclonal Antibody

Chicken Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
PIPA5143547	Invitrogen™ PA5143547	500 μL
PIPA5143581	Invitrogen™ PA5143581	100 μL

Description

alpha Synuclein Polyclonal Antibody for Western Blot, ICC/IF, IHC (P), IHC (PFA)

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. These proteins are abundant in the brain and play a role in regulating synaptic transmission and membrane trafficking. Alpha- and beta-synuclein have been shown to selectively inhibit phospholipase D2, suggesting that they may also be involved in signaling pathways. Defects in the SNCA gene, which encodes alpha-synuclein, have been implicated in the pathogenesis of Parkinson's disease. Additionally, alpha-synuclein peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Multiple alternatively spliced transcripts encoding different isoforms have been identified for this gene. Diseases associated with SNCA include Parkinson Disease 1, Autosomal Dominant and Dementia, Lewy Body.

Specifications

• Antigen: alpha Synuclein
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Classification: Polyclonal
• Form: Liquid
• Isotype: IgY
• Target Species: Human, Mouse, Rat, Bovine, Pig, Horse
• Gene: SNCA
• Gene Alias: Alpha synuclein; alphaSYN; alpha-synuclein; NACP; non A-beta component of AD amyloid; non-A beta component of AD amyloid; non-A4 component of amyloid; Non-A4 component of amyloid precursor; PARK1; PARK4; PD1; Snca; Syn; synuclein alpha; synuclein alpha-140; synuclein, alpha; synuclein, alpha (non A4 component of amyloid precursor)
• Gene Symbols: SNCA
• Primary or Secondary: Primary
• Purification Method: Affinity chromatography

• Concentration: 1 mg/mL
• Applications: Immunohistochemistry (Paraffin), Immunohistochemistry (PFA fixed), Western Blot, Immunocytochemistry
• Conjugate: Unconjugated
• Host Species: Chicken
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 5mM sodium azide
• Gene Accession No.: O55042, P37377, P37840, Q3I5G7, Q3T0G8
• Gene ID (Entrez): 100053270, 20617, 282857, 29219, 641350, 6622
• Immunogen: Full length recombinant human protein expressed in and purified from E. coli.
• Product Type: Antibody