ALPL Mouse anti-Human, Clone: 2F4, Abnova™

Catalog No.	Quantity
89-933-560	50 μg

Catalog No. 89-933-560 Supplier Abnova Corporation Supplier No. MAB12991

Description

Mouse monoclonal antibody raised against partial recombinant human ALPL.

There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq]

Specifications

• Antigen: ALPL
• Applications: ELISA, Flow Cytometry, Immunohistochemistry (PFA fixed), Western Blot
• Classification: Monoclonal
• Clone: 2F4
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against partial recombinant human ALPL.
• Dilution: ELISA (1:10000) Flow Cytometry (1:200-1:400) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:200) Western Blot (1:500-1:2000) The optimal working dilution should be determined by the end user.
• Formulation: In PBS (0.05% protein stabilizer, 0.05% sodium azide).
• Gene Alias: AP-TNAP/FLJ40094/FLJ93059/HOPS/MGC161443/MGC167935/TNAP/TNSALP
• Gene Symbols: ALPL
• Host Species: Mouse
• Immunogen: Recombinant protein corresponding to amino acids 18-502 of human ALPL.
• Purification Method: Protein G purification
• Quantity: 50 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 249
• Target Species: Human
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid
• Isotype: IgG1