Invitrogen™ ALS2CR2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5110917

Catalog No. PIPA5110917

Description

Immunogen sequence: FSPAFFSLVQ LCLQQDPEKR PSASSLLSHV FFKQMKEESQ DSILSLLPPA YNKPSISLPP VLPWTEPECD FPDE.

This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene.

Specifications

• Antigen: ALS2CR2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: STRADB
• Gene Alias: AA792893; Als2cr2; amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2; amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog; B830008M19; CALS-21; D1Ucla2; ILP-interacting protein; ILP-interacting protein homolog; ILP-interacting protein ILPIPA; ILPIP; ILPIPA; MGC102916; Papk; polyploidy associated protein kinase; polyploidy associated protein kinase PAPK-A; polyploidy-associated protein kinase; PRO1038; pseudokinase ALS2CR2; RGD1559449; STE20 related adaptor beta; STE20-related kinase adapter protein beta; STE20-related kinase adaptor beta; STRAD beta; Stradb; Syradb
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 227154, 55437
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.30 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q8K4T3, Q9C0K7
• Gene Symbols: STRADB
• Immunogen: Recombinant Protein corresonding to Human ALS2CR2. Recombinant protein control fragment (Product #RP-95062).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG