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Invitrogen™ ALX3 Polyclonal Antibody
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Catalog No. PIPA568566
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PIPA568566 100 μL
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Catalog No. PIPA568566 Supplier Invitrogen™ Supplier No. PA568566
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Description

Rabbit Polyclonal Antibody

This target displays homology in the following species: Cow: 100%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 93%; Rabbit: 100%; Rat: 93%.

Aristaless-related genes are a group of paired-related homeobox genes which play a role in regulating vertebrate embryogenesis. The homeodomain transciption factor aristaless-like 3 (ALX3) is expressed in mouse embryos from 8 days of gestation, predominantly in neural crest-derived mesenchyme and in lateral plate mesoderm. Expression analysis of human and mouse tissue reveals predominant ALX3 expression in brain tissue. The Alx3 gene maps to chromosome 1p23-p13 and encodes a 343 amino acid protein. Preferential methylation of Alx3 occurs in advanced-stage neuroblastoma and may repress ALX3 expression. Treatment with the methylation inhibitor 5-aza-2'-deoxycytidine restores ALX3 expression. Alx3 (-) mice lack a phenotype distinct from wild-type mice, however Alx3/Alx4 double mutants demonstrate severe craniofacial abnormalities not present in Alx4 single mutants. Specifically, Alx3/Alx4 double mutant newborn mice have cleft nasal regions in addition to malformation of other neural crest-derived skull structures.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ALX3
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene ALX3
Gene Accession No. 0
Gene Alias ALX homeobox 3; ALX3; aristaless 3; aristaless-like homeobox 3; FND; FND1; frontonasal dysplasia; homeobox protein aristaless-like 3; Proline-rich transcription factor ALX3
Gene Symbols ALX3
Host Species Rabbit
Immunogen synthetic peptide directed towards the middle region of rat ALX3.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 365900
Target Species Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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