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R&D Systems™ AM 9022
SDP

Catalog No. RD10193519 Shop All Novus Products
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5 mg
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RD10193519 5 mg
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Catalog No. RD10193519 Supplier R&D Systems™ Supplier No. 8969/5

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Description

A Tocris product, part of R&D Systems.

AM 9022 is a potent and selective KIF18A inhibitor (IC50 = 60 nM). Displays selectivity for KIF18A over a panel of diverse kinesin motor proteins. Upon blocking MT-ATPase motor activity (non-competitive with ATP and MTs), it activates the mitotic checkpoint and selectively kills chromosomally unstable cancer cells. In mice, AM 9022 leads to tumor regression. AM 9022 can be used for the selective targeting of CIN cancers.

Specifications

Chemical Name or Material 2-(6-Azaspiro[2.5]oct-6-yl)-N-[2-(4,4-difluoro-1-piperidinyl)-6-methyl-4-pyrimidinyl]-4-[[[(1R)-2-hydroxy-1-methylethyl]sulfonyl]amino]benzamide
CAS 2446872-46-2
Quantity 5 mg
Product Line Tocris
Target Checkpoint Kinase Inhibitors
Molecular Formula C27H36F2N6O4S
Purity 98%
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