AM3 Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-7500	100 μL

Catalog No. 50-198-7500 Supplier Bioss Supplier No. BS6791R

Description

Rabbit Polyclonal Antibody

Apoptosis, also known as programmed cell death, plays major roles in development and normal tissue turnover in addition to tumor formation. Recently a protein similar to the apoptosis-inducing factor (AIF) was cloned and designated AIFL (also known as AIFM3). AIFM3 is expressed ubiquitously and is predominantly localized to the inner membranes of mitochondria. Unlike AIF, AIFM3 does not translocate to the nucleus upon induction of apoptosis. However, overexpression of AIFM3, like AIF, induced cytochrome c release from the mitochondria, cleavage of caspase 3, and ultimately apoptosis, indicating AIFM3 induces apoptosis through caspase activation. Multiple isoforms of AIFM3 are known to exist.

Specifications

• Antigen: AM3
• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: AIFM3
• Gene Accession No.: Q96NN9
• Gene Alias: 2810401C16Rik; AI840249; AIFL; Aifm3; apoptosis inducing factor, mitochondria associated 3; Apoptosis-inducing factor 3; apoptosis-inducing factor like; apoptosis-inducing factor, mitochondrion-associated 3; apoptosis-inducing factor, mitochondrion-associated, 3; Apoptosis-inducing factor-like protein; RGD1306028
• Gene Symbols: AIFM3
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide derived from mouse AIFM3 (21-65aa).
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 150209
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG