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Invitrogen™ AMER1 Polyclonal Antibody
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Catalog No. PIPA584686
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100 μL
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PIPA584686 100 μL
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Catalog No. PIPA584686 Supplier Invitrogen™ Supplier No. PA584686
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: DSLENSPPGD DCLYDLHGRS SEMFDPFLNF EPFLSSRPPG AMETEEERLV TIQKQLLYWE LRREQLEAQE ARAREAHARE Highest antigen sequence indentity to the following orthologs: Mouse - 90%, Rat - 90%.

The AMER1 gene encodes the protein APC membrane recruitment 1, also known as Wilms tumor 1-associating protein (WT1-associating protein). This protein plays a significant role in the Wnt signaling pathway, which is critical for cellular processes such as proliferation, differentiation, and migration. AMER1 interacts with the adenomatous polyposis coli (APC) protein and is involved in the regulation of β-catenin, a key mediator of Wnt signaling. By recruiting APC to the cell membrane, AMER1 facilitates the degradation of β-catenin, thereby acting as a negative regulator of the pathway. This function is vital in maintaining cellular homeostasis and preventing uncontrolled cell growth. Mutations or dysregulation of AMER1 are associated with various cancers, including colorectal cancer, as aberrant Wnt signaling can lead to oncogenesis. Moreover, germline mutations in AMER1 are linked to conditions such as osteoporosis-pseudoglioma syndrome, highlighting its role in bone development and eye health. Ongoing research focuses on elucidating the detailed mechanisms of AMER1's involvement in signaling pathways and its potential as a therapeutic target in cancer and genetic disorders.
TRUSTED_SUSTAINABILITY

Specifications

Antigen AMER1
Applications Immunocytochemistry
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene AMER1
Gene Accession No. Q5JTC6
Gene Alias 2810002O09Rik; adenomatous polyposis coli membrane recruitment 1; Amer1; APC membrane recruitment 1; APC membrane recruitment protein 1; AW492303; Fam123b; family with sequence similarity 123, member B; family with sequence similarity 123B; OSCS; protein Fam123b; RGD1560322; RP11-403E24.2; Wilms tumor gene on the X chromosome protein; Wilms tumor on the X; WTX
Gene Symbols AMER1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human AMER1. Recombinant protein control fragment (Product #RP-107416).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 139285
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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