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Tocris Bioscience™ AMG 21629
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Catalog No. 43301
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43301 1 mg
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Catalog No. 43301 Supplier Tocris Bioscience™ Supplier No. 4330/1
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Description

Potent and selective TRPV1 antagonist

AMG 21629 is a potent and selective TRPV1 antagonist. Blocks Ca2+ uptake by CHO cells expressing TRPV1 receptors (IC50 values are 0.6 and 0.8 nM for capsaicin (Cat. No. 0462) and acid-induced Ca2+ uptake, respectively). Exhibits >4000-fold selectivity for TRPV1 over other TRP channels. Blocks capsaicin-induced flinch response and causes hyperthermia in rats. Orally available and non-CNS penetrant.

Specifications

Chemical Name or Material 3-Amino-5-[[2-[(2-methoxyethyl)amino]-6-[4-(trifluoromethyl)phenyl]-4-pyrimidinyl]oxy]-2(1H)-quinoxalinone
CAS 939040-79-6
Quantity 1 mg
Target TRPV Antagonists
Molecular Formula C22H19F3N6O3
Formula Weight 472.42
Purity >97%
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