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Tocris Bioscience™ (±)-AMG 487
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Catalog No. 448750
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Catalog No. Quantity
44-875-0 50 mg
44-871-0 10 mg
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Catalog No. 44-875-0 Supplier Tocris Bioscience™ Supplier No. 4487/50
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Description

CXCR3 antagonist; inhibits cell migration and metastasis

(±)-AMG 487 is an antagonist of CXCR3; inhibits binding of 125I-IP-10 and 125I-ITAC to CXCR3 (IC50 values are 8.0 and 8.2 nM respectively). Inhibits CXCR3-mediated cell migration by the chemokines IP-10, ITAC and MiG in vitro (IC50 values are 8, 15 and 36 nM respectively). Also shown to inhibit lung metastasis in a mouse model of metastatic breast cancer.

This product is racemic.

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Chemical Identifiers

CAS 947536-03-0
Molecular Formula C32H28F3N5O4

Specifications

Quantity 50 mg
Formula Weight 603.59
Purity >98%
Molecular Weight (g/mol) 603.602
Chemical Name or Material (±)-AMG 487

Safety and Handling

Recommended Storage Store at -20°C
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