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Tocris Bioscience™ AMG 510
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Catalog No. 771350
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77-135-0 50 mg
77-131-0 10 mg
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Catalog No. 77-135-0 Supplier Tocris Bioscience™ Supplier No. 7713/50
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Description

Potent and selective KRASG12C inhibitor

AMG 510 is a potent and selective covalent KRASG12C inhibitor (IC50 = 90 nM). Also a potent inhibitor of phospho-ERK (IC50 = 68 nM). In an in vivo model of non-small cell lung cancer, AMG 510 causes regression of tumors, an increase in T-cell recruitment and a pro-inflammatory tumor microenvironment. Synergises with MEK inhibitors and Carboplatin (Cat. No. 2626) and is orally bioavailable.

Specifications

Chemical Name or Material (1 R)-6-Fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-4-[(2 S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-2(1 H)-one
CAS 2252403-56-6
Quantity 50 mg
Target Ras GTPase Inhibitors
Molecular Formula C30H30F2N6O3
Purity 0.98
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