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Tocris Bioscience™ AMG 900
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Catalog No. 786550
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78-655-0 50 mg
78-651-0 10 mg
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Catalog No. 78-655-0 Supplier Tocris Bioscience™ Supplier No. 7865/50
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Description

Potent pan-Aurora kinase inhibitor

AMG 900 is a potent pan-Aurora kinase inhibitor (IC50 values are 1 nM, 4 nM, and 5 nM for Aurora C, B, and A, respectively). It is more than 10-fold selective for Aurora kinases over JNK2, Tie2, p38α, Met, and TYK2. AMG 900 inhibits autophosphorylation of Aurora A and B, as well as the phosphorylation of histone H3 on Ser in HeLa cells. AMG 900 inhibits proliferation of 26 tumor cell lines (EC50 ranges from 0.7 nM - 5.3 nM), including Paclitaxel (Cat. No. 1097)-resistant tumor cell lines. In an HCT116 tumor xenograft model, AMG 900 inhibits phosphorylation of histone H3 and tumor growth. It is orally bioavailable.

Specifications

Chemical Name or Material N-[4-[[3-(2-Amino-4-pyrimidinyl)-2-pyridinyl]oxy]phenyl]-4-(4-methyl-2-thienyl)-1-phthalazinamine
CAS 945595-80-2
Quantity 50 mg
Target Aurora Kinase Inhibitors
Molecular Formula C28H21N7OS
Purity 98%
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