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Invitrogen™ AMICA Monoclonal Antibody (401901)
Mouse Monoclonal Antibody
Supplier: Invitrogen™ MA524138
Description
In direct ELISAs and Western blots, no cross-reactivity with recombinant mouse AMICA is observed. Reconstitute at 0.5 mg/mL in sterile PBS.
AMICA transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.
Specifications
AMICA | |
Monoclonal | |
0.5 mg/mL | |
PBS with 5% trehalose and No Preservative | |
Q86YT9 | |
JAML | |
Mouse myeloma cell line NS0-derived recombinant human AMICA/JAML Leu20-Leu275. | |
100 μg | |
Primary | |
Human | |
Antibody | |
IgG2a |
Flow Cytometry | |
401901 | |
Unconjugated | |
JAML | |
adhesion molecule AMICA; adhesion molecule interacting with CXADR antigen 1; adhesion molecule, interacts with CXADR antigen 1; AMICA; Amica1; Crea7; CREA7-1; CREA7-4; Dendritic cell-specific protein CREA7; Dendritic cell-specific protein CREA7-1; dendritic-cell specific protein Crea7; dendritic-cell specific protein CREA7-1; dendritic-cell specific protein CREA7-4; Gm638; Jaml; junction adhesion molecule like; junctional adhesion molecule-like; mCrea7; UNQ722/PRO1387 | |
Mouse | |
Protein A/G | |
RUO | |
120425 | |
-20°C, Avoid Freeze/Thaw Cycles | |
Lyophilized |
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