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Invitrogen™ AMID Polyclonal Antibody
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Catalog No. PIPA588365
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100 μL
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PIPA588365 100 μL
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Catalog No. PIPA588365 Supplier Invitrogen™ Supplier No. PA588365
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: KDSFHHNVAA LRASVETGFA KKTFISYSVT FKDNFRQGLV VGIDLKNQMV LLQGGEALPF SHLILATGST GPFPGKFNEV SSQQAAIQAY EDMVRQVQRS RFIVVVGGGS AGVEMAAEIK TEYPEKEVTL IHSQVALADK ELLPSVRQEV KEILLRKGVQ LLLSERVSNL EELPLNEYRE YIKVQTDKGT EVATNLVILC TGIKINSSAY RKAFESRLAS SGALRVNEHL QVEGHSNVYA IGDCADVRTP KMAYLAGLHA NIAVANIVNS VKQRPLQAYK PGALTFLLSM GRNDGVGQIS GFYVGRLMVR LTKSRDLFVS TSWKTMRQS Positive Samples: HepG2, A-549; Cellular Location: Cytoplasm, Lipid-anchor, Membrane, Mitochondrion outer membrane.

The p53 tumor suppressor protein induces cell cycle arrest or apoptosis in response to cellular stresses. PRG3 (p53-responsive gene 3), is induced specifically under p53-dependent apoptotic conditions in human colon cancer cells. PRG3 has significant homology to bacterial oxidoreductases and the apoptosis-inducing factor, AIF. Unlike AIF, PRG3 localizes in the cytoplasm and its ectopic expression induces apoptosis. The PRG3 gene is thus a novel p53 target gene in a p53-dependent apoptosis pathway.
TRUSTED_SUSTAINABILITY

Specifications

Antigen AMID
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.94 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene AIFM2
Gene Accession No. Q8BUE4, Q9BRQ8
Gene Alias 5430437E11Rik; AIFM2; Amid; apoptosis inducing factor, mitochondria associated 2; apoptosis-inducing factor (AIF)-homologous mitochondrion-associated inducer of death; apoptosis-inducing factor (AIF)-like mitochondrion-associated inducer of death; apoptosis-inducing factor 2; Apoptosis-inducing factor homologous mitochondrion-associated inducer of death; apoptosis-inducing factor, mitochondrion-associated 2; apoptosis-inducing factor, mitochondrion-associated, 2; apoptosis-inducing factor-like mitchondrion-associated inducer of death; apoptosis-inducing factor-like mitochondrion-associated inducer of death; D730001I10Rik; MBP2; MBPH; MGC126662; MGC141971; p53-responsive gene 3 protein; PRG3; RP11-367H5.2
Gene Symbols AIFM2
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 43-371 of human AIFM2/FSP1/AMID/AMID (NP_1161861).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 361843, 71361, 84883
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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