Invitrogen™ AMID Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA588365

Catalog No. PIPA588365

Description

Immunogen sequence: KDSFHHNVAA LRASVETGFA KKTFISYSVT FKDNFRQGLV VGIDLKNQMV LLQGGEALPF SHLILATGST GPFPGKFNEV SSQQAAIQAY EDMVRQVQRS RFIVVVGGGS AGVEMAAEIK TEYPEKEVTL IHSQVALADK ELLPSVRQEV KEILLRKGVQ LLLSERVSNL EELPLNEYRE YIKVQTDKGT EVATNLVILC TGIKINSSAY RKAFESRLAS SGALRVNEHL QVEGHSNVYA IGDCADVRTP KMAYLAGLHA NIAVANIVNS VKQRPLQAYK PGALTFLLSM GRNDGVGQIS GFYVGRLMVR LTKSRDLFVS TSWKTMRQS Positive Samples: HepG2, A-549; Cellular Location: Cytoplasm, Lipid-anchor, Membrane, Mitochondrion outer membrane.

The p53 tumor suppressor protein induces cell cycle arrest or apoptosis in response to cellular stresses. PRG3 (p53-responsive gene 3), is induced specifically under p53-dependent apoptotic conditions in human colon cancer cells. PRG3 has significant homology to bacterial oxidoreductases and the apoptosis-inducing factor, AIF. Unlike AIF, PRG3 localizes in the cytoplasm and its ectopic expression induces apoptosis. The PRG3 gene is thus a novel p53 target gene in a p53-dependent apoptosis pathway.

Specifications

• Antigen: AMID
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: AIFM2
• Gene Alias: 5430437E11Rik; AIFM2; Amid; apoptosis inducing factor, mitochondria associated 2; apoptosis-inducing factor (AIF)-homologous mitochondrion-associated inducer of death; apoptosis-inducing factor (AIF)-like mitochondrion-associated inducer of death; apoptosis-inducing factor 2; Apoptosis-inducing factor homologous mitochondrion-associated inducer of death; apoptosis-inducing factor, mitochondrion-associated 2; apoptosis-inducing factor, mitochondrion-associated, 2; apoptosis-inducing factor-like mitchondrion-associated inducer of death; apoptosis-inducing factor-like mitochondrion-associated inducer of death; D730001I10Rik; MBP2; MBPH; MGC126662; MGC141971; p53-responsive gene 3 protein; PRG3; RP11-367H5.2
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 361843, 71361, 84883
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.94 mg/mL
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene Accession No.: Q8BUE4, Q9BRQ8
• Gene Symbols: AIFM2
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 43-371 of human AIFM2/FSP1/AMID/AMID (NP_1161861).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov