Invitrogen™ Aminoacylase Monoclonal Antibody (15G2)

Catalog No.	Quantity
PIMA537803	100 μL

Catalog No. PIMA537803 Supplier Invitrogen™ Supplier No. MA537803

Description

Mouse Monoclonal Antibody

Positive controls: Rat kidney tissue lysate, human liver tissue lysate, Rat liver tissue, human liver tissue, human kidney tissue, mouse small intestine tissue, SHSY5Y.

ACY1 encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21. 1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene. A related pseudogene has been identified on chromosome 18.

Specifications

• Antigen: Aminoacylase
• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
• Classification: Monoclonal
• Clone: 15G2
• Concentration: 2 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol, 0.2% BSA and 0.05% sodium azide; pH 7.4
• Gene: ACY1
• Gene Accession No.: Q03154, Q6AYS7, Q99JW2
• Gene Alias: 1110014J22Rik; ACY IA; ACY IB; ACY1; ACY-1; Acy1a; ACY-1A; Acy1b; ACY-1B; ACY1D; acylase; aminoacylase 1; aminoacylase I; aminoacylase-1; Aminoacylase-1A; aminoacylase-1B; epididymis secretory protein Li 5; HEL-S-5; N-acylamino acid aminohydrolase (Aminoacylase 1); N-acyl-L-amino-acid amidohydrolase
• Gene Symbols: ACY1
• Host Species: Mouse
• Immunogen: Recombinant protein within Human ACY1 aa 55-256.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 109652, 300981, 95
• Target Species: Human, Mouse, Rat
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2a