Invitrogen™ Aminoacylase Monoclonal Antibody (02)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA528995

Catalog No. PIMA528995

Description

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%). This antibody has specificity for Human ACY1/Aminoacylase-1.

ACY1 encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21. 1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene. A related pseudogene has been identified on chromosome 18.

Specifications

• Antigen: Aminoacylase
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with no preservative
• Gene Accession No.: Q03154
• Gene Symbols: ACY1
• Immunogen: Recombinant Human ACY1/Aminoacylase-1 protein (Met1-Ser408).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry (Paraffin)
• Clone: 02
• Conjugate: Unconjugated
• Gene: ACY1
• Gene Alias: 1110014J22Rik; ACY IA; ACY IB; ACY1; ACY-1; Acy1a; ACY-1A; Acy1b; ACY-1B; ACY1D; acylase; aminoacylase 1; aminoacylase I; aminoacylase-1; Aminoacylase-1A; aminoacylase-1B; epididymis secretory protein Li 5; HEL-S-5; N-acylamino acid aminohydrolase (Aminoacylase 1); N-acyl-L-amino-acid amidohydrolase
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 95
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid