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Invitrogen™ Aminoacylase Polyclonal Antibody
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Catalog No. PIPA5118946
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200 μL
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PIPA5118946 200 μL
PIPA5122287 20 μL
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Catalog No. PIPA5118946 Supplier Invitrogen™ Supplier No. PA5118946
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Description

Rabbit Polyclonal Antibody

Aminoacylase Polyclonal Antibody for Western Blot, IHC (P)

ACY1 encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21. 1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene. A related pseudogene has been identified on chromosome 18.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Aminoacylase
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.4
Gene ACY1
Gene Accession No. P37111, Q03154
Gene Alias 1110014J22Rik; ACY IA; ACY IB; ACY1; ACY-1; Acy1a; ACY-1A; Acy1b; ACY-1B; ACY1D; acylase; aminoacylase 1; aminoacylase I; aminoacylase-1; Aminoacylase-1A; aminoacylase-1B; epididymis secretory protein Li 5; HEL-S-5; N-acylamino acid aminohydrolase (Aminoacylase 1); N-acyl-L-amino-acid amidohydrolase
Gene Symbols ACY1
Host Species Rabbit
Immunogen Recombinant protein Aminoacylase 1. The antigen corresponds to amino acid range 2-408 of the target protein.
Purification Method Antigen affinity chromatography, Protein A
Quantity 200 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 396930, 95
Target Species Human, Pig
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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