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  7. Aminopurvalanol A, Tocris Bioscience™

Aminopurvalanol A, Tocris Bioscience™

Catalog No. 207250
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Selective cdk inhibitor; potently inhibits cdk1, cdk2 and cdk5

Cyclin-dependent kinase (cdk) inhibitor (reported IC50 values are 20 - 35 nM for cdk1, cdk2 and cdk5). Also inhibits ERK1 (IC50 = 12.0 μM) and ERK2 (IC50 = 3.1 μM) and is 3000-fold selective over a range of other protein kinases (IC50 >100 μM). Arrests cell cycle at G2/M boundary (IC50 = 1.25 μM), and induces apoptosis at concentrations >10 μM. Cell permeable.

Chemical Identifiers

CAS 220792-57-4
Molecular Formula C19H26ClN7O
Molecular Weight (g/mol) 403.915
InChI Key RAMROQQYRRQPDL-UHFFFAOYSA-N
Synonym d0dm5s, aminopurvalanol a and ng-97
PubChem CID 9549304
IUPAC Name 2-[[6-(3-amino-5-chloroanilino)-9-propan-2-ylpurin-2-yl]amino]-3-methylbutan-1-ol
SMILES CC(C)C(CO)NC1=NC2=C(C(=N1)NC3=CC(=CC(=C3)N)Cl)N=CN2C(C)C

Specifications

Quantity 50 mg
Formula Weight 403.91
Percent Purity >98%
Chemical Name or Material Aminopurvalanol A

Safety and Handling

Recommended Storage Store at +4°C
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