Invitrogen™ AMOTL2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5120481

Catalog No. PIPA5120481

Description

Positive test controls include: 293T, U-251MG, HepG2, Mouse liver, Mouse brain. Immunogen sequence: RQFAMDAAAT AAAQRDTTLI RHSPQPSPSS SFNEGLLTGG HRHQEMESRL KVLHAQILEK DAVIKVLQQR SRRDPGKAIQ GSLRPAKSVP SVFAAAAAGT QGWQGLSSSE RQTADAPARL TTDRAPTEEP VVTAPPAAHA KHGSRDGSTQ TEGPPDSTST CLPPEPDSLL GCSSSQRAAS LDSVATSRVQ DLSDMVEILI.

Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC.

Specifications

• Antigen: AMOTL2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: AMOTL2
• Gene Alias: AMOTL2; angiomotin like 2; angiomotin-like 2; angiomotin-like protein 2; AW549739; C79691; KIAA0989; LCCP; Leman coiled-coil protein; MASCOT; mKIAA0989
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 51421, 56332
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 2.14 mg/mL
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene Accession No.: Q8K371, Q9Y2J4
• Gene Symbols: AMOTL2
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 638-837 of human AMOTL2 (NP_001265612.1).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG