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Invitrogen™ Amphiphysin Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA582701

Catalog No. PIPA582701


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Description

Description

Immunogen sequence: EKVIPSVVIE PASNHEEEGE NEITIGAEPK ETTEDAAPPG PTSETPELAT EQKPIQDPQP TPSAPAMGAA DQLASAREA.

Amphiphysins, members of the BAR (Bin-Amphiphysin-Rvsp) protein super family, play a key role in clathrin-mediated endocytosis of synaptic vesicles (SVs). All members of the BAR family share a highly conserved N-terminal BAR domain and a C-terminal Src homology (SH3) domain. Two isoforms of amphiphysin have been identified and act in concert as a heterodimer. Amphiphysins interact via its carboxy-terminal SH3 domain with dynamin, synaptojanin and clathrin. These complexes are implicated in synaptic vesicle recycling at nerve terminal. Amphiphysins were also identified as the dominant autoantigen in paraneoplastic Stiff-Man Syndrome.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

Amphiphysin
Polyclonal
Unconjugated
Amph
Amph; AMPH1; amphiphysin; amphiphysin (Stiff-Mann syndrome with breast cancer 128kD autoantigen); amphiphysin 1; amphiphysin I; HGNC:471
Rabbit
Antigen affinity chromatography
RUO
273
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
0.2 mg/mL
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
P49418
Amph
Recombinant protein corresponding to Human AMPH. Recombinant protein control fragment (Product #RP-92624).
100 μL
Primary
Human, Mouse
Antibody
IgG
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