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Invitrogen™ Amphiphysin Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA582701
Description
Immunogen sequence: EKVIPSVVIE PASNHEEEGE NEITIGAEPK ETTEDAAPPG PTSETPELAT EQKPIQDPQP TPSAPAMGAA DQLASAREA.
Amphiphysins, members of the BAR (Bin-Amphiphysin-Rvsp) protein super family, play a key role in clathrin-mediated endocytosis of synaptic vesicles (SVs). All members of the BAR family share a highly conserved N-terminal BAR domain and a C-terminal Src homology (SH3) domain. Two isoforms of amphiphysin have been identified and act in concert as a heterodimer. Amphiphysins interact via its carboxy-terminal SH3 domain with dynamin, synaptojanin and clathrin. These complexes are implicated in synaptic vesicle recycling at nerve terminal. Amphiphysins were also identified as the dominant autoantigen in paraneoplastic Stiff-Man Syndrome.
Specifications
Amphiphysin | |
Polyclonal | |
Unconjugated | |
Amph | |
Amph; AMPH1; amphiphysin; amphiphysin (Stiff-Mann syndrome with breast cancer 128kD autoantigen); amphiphysin 1; amphiphysin I; HGNC:471 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
273 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry | |
0.2 mg/mL | |
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
P49418 | |
Amph | |
Recombinant protein corresponding to Human AMPH. Recombinant protein control fragment (Product #RP-92624). | |
100 μL | |
Primary | |
Human, Mouse | |
Antibody | |
IgG |
Safety and Handling
WARNING: Cancer - www.P65Warnings.ca.gov
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