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Invitrogen™ Amphiphysin Polyclonal Antibody
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Catalog No. PIPA582702
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100 μL
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Catalog No. Quantity
PIPA582702 100 μL
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Catalog No. PIPA582702 Supplier Invitrogen™ Supplier No. PA582702
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: PGFLYKVETL HDFEAANSDE LTLQRGDVVL VVPSDSEADQ DAGWLVGVKE SDWLQYRDLA TYKGLFPENF TRRL Highest antigen sequence indentity to the following orthologs: Mouse - 99%, Rat - 99%.

Amphiphysins, members of the BAR (Bin-Amphiphysin-Rvsp) protein super family, play a key role in clathrin-mediated endocytosis of synaptic vesicles (SVs). All members of the BAR family share a highly conserved N-terminal BAR domain and a C-terminal Src homology (SH3) domain. Two isoforms of amphiphysin have been identified and act in concert as a heterodimer. Amphiphysins interact via its carboxy-terminal SH3 domain with dynamin, synaptojanin and clathrin. These complexes are implicated in synaptic vesicle recycling at nerve terminal. Amphiphysins were also identified as the dominant autoantigen in paraneoplastic Stiff-Man Syndrome.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Amphiphysin
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.4 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Amph
Gene Accession No. P49418
Gene Alias Amph; AMPH1; amphiphysin; amphiphysin (Stiff-Mann syndrome with breast cancer 128kD autoantigen); amphiphysin 1; amphiphysin I; HGNC:471
Gene Symbols Amph
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human AMPH. Recombinant protein control fragment (Product #RP-92625).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 273
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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