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Amphiphysin Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501984702
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50-198-4702 100 μL
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Catalog No. 50-198-4702 Supplier Bioss Supplier No. BS2409R
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Description

Rabbit Polyclonal Antibody

Amphiphysins, members of the BAR (Bin-Amphiphysin-Rvsp) protein super family, play a key role in clathrin-mediated endocytosis of synaptic vesicles (SVs). All members of the BAR family share a highly conserved N-terminal BAR domain and a C-terminal Src homology (SH3) domain. Two isoforms of amphiphysin have been identified and act in concert as a heterodimer. Amphiphysins interact via its carboxy-terminal SH3 domain with dynamin, synaptojanin and clathrin. These complexes are implicated in synaptic vesicle recycling at nerve terminal. Amphiphysins were also identified as the dominant autoantigen in paraneoplastic Stiff-Man Syndrome.

Specifications

Antigen Amphiphysin
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene Amph
Gene Accession No. P49418
Gene Alias Amph; Amph1; Amphiphysin; amphiphysin (Stiff-Mann syndrome with breast cancer 128kD autoantigen); amphiphysin 1; amphiphysin I; HGNC:471
Gene Symbols Amph
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human Amphiphysin.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 273
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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