Invitrogen™ Amphiregulin Monoclonal Antibody (A3)

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
PIMA541547	Invitrogen™ MA541547	200 μL
PIMA543966	Invitrogen™ MA543966	20 μL

Description

Amphiregulin Monoclonal Antibody for Western Blot, ICC/IF, IHC (P)

Amphiregulin (AR) binds to EGF-Receptor (EGFR) with lower affinity than EGF. The mature secreted form AR is an 84-amino acid residue glycosylated polypeptide growth regulator, which is generated by proteolytic processing of a 252-amino acid transmembrane precursor. Seven different polypeptide ligands, which derive from distinct genes, are capable of binding to the extracellular domain of EGFR. These ligands include EGF, TGFalpha, AR, HB-EGF, cripto-1, epiregulin, and betacellulin. All of these growth factors contain a characteristic EGF-like domain which is defined by 6 evenly spaced cysteine residues that generate 3 loops through the formation of disulfide bonds. AR protein has been localized by immunohistochemistry to the epithelium of the colon, stomach, pancreas, breast, and placenta. AR is reportedly overexpressed in human cancers of breast, colon, stomach, and pancreas.

Specifications

• Antigen: Amphiregulin
• Concentration: 1 mg/mL
• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Conjugate: Unconjugated
• Host Species: Mouse
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300
• Gene Accession No.: P15514
• Gene ID (Entrez): 374
• Immunogen: Recombinant protein Amphiregulin. The antigen corresponds to amino acid range 20-100 of the target protein.
• Product Type: Antibody

• Clone: A3
• Content And Storage: -20°C
• Classification: Monoclonal
• Form: Liquid
• Isotype: IgG2b κ
• Target Species: Human
• Gene: AREG
• Gene Alias: amphiregulin; amphiregulin B; AR; AREG; AREGB; colorectum cell-derived growth factor; CRDGF; Mcub; MGC13647; schwannoma-derived growth factor; SDGF
• Gene Symbols: AREG
• Primary or Secondary: Primary
• Purification Method: Protein A/G