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Invitrogen™ Amphiregulin Polyclonal Antibody
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Catalog No. PIPA516621
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500 μL
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Catalog No. Quantity
PIPA516621 500 μL
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Catalog No. PIPA516621 Supplier Invitrogen™ Supplier No. PA516621
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Description

Rabbit Polyclonal Antibody

PA5-16621 targets Amphiregulin in IP and WB applications and shows reactivity with Human and mouse samples. The PA5-16621 immunogen is a synthetic 19-mer peptide, corresponding to aa 26-44 from the secreted amphiregulin of human origin.

Amphiregulin (AR) binds to EGF-Receptor (EGFR) with lower affinity than EGF. The mature secreted form AR is an 84-amino acid residue glycosylated polypeptide growth regulator, which is generated by proteolytic processing of a 252-amino acid transmembrane precursor. Seven different polypeptide ligands, which derive from distinct genes, are capable of binding to the extracellular domain of EGFR. These ligands include EGF, TGFalpha, AR, HB-EGF, cripto-1, epiregulin, and betacellulin. All of these growth factors contain a characteristic EGF-like domain which is defined by 6 evenly spaced cysteine residues that generate 3 loops through the formation of disulfide bonds. AR protein has been localized by immunohistochemistry to the epithelium of the colon, stomach, pancreas, breast, and placenta. AR is reportedly overexpressed in human cancers of breast, colon, stomach, and pancreas.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Amphiregulin
Applications Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
Gene AREG
Gene Accession No. P15514, P31955
Gene Alias amphiregulin; amphiregulin B; AR; AREG; AREGB; colorectum cell-derived growth factor; CRDGF; Mcub; MGC13647; schwannoma-derived growth factor; SDGF
Gene Symbols AREG
Host Species Rabbit
Immunogen A synthetic 19-mer peptide, corresponding to aa 26-44 from the secreted amphiregulin of human origin.
Purification Method Protein A
Quantity 500 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11839, 374
Target Species Human, Mouse
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG
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