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Invitrogen™ Amphiregulin Polyclonal Antibody
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Catalog No. PIPA527298
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100 μL
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PIPA527298 100 μL
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Catalog No. PIPA527298 Supplier Invitrogen™ Supplier No. PA527298
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: AREG-transfected 293T. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Amphiregulin (AR) binds to EGF-Receptor (EGFR) with lower affinity than EGF. The mature secreted form AR is an 84-amino acid residue glycosylated polypeptide growth regulator, which is generated by proteolytic processing of a 252-amino acid transmembrane precursor. Seven different polypeptide ligands, which derive from distinct genes, are capable of binding to the extracellular domain of EGFR. These ligands include EGF, TGFalpha, AR, HB-EGF, cripto-1, epiregulin, and betacellulin. All of these growth factors contain a characteristic EGF-like domain which is defined by 6 evenly spaced cysteine residues that generate 3 loops through the formation of disulfide bonds. AR protein has been localized by immunohistochemistry to the epithelium of the colon, stomach, pancreas, breast, and placenta. AR is reportedly overexpressed in human cancers of breast, colon, stomach, and pancreas.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Amphiregulin
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.17 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 20% glycerol and 0.025% ProClin 300; pH 7
Gene AREG
Gene Accession No. P15514
Gene Alias amphiregulin; amphiregulin B; AR; AREG; AREGB; colorectum cell-derived growth factor; CRDGF; Mcub; MGC13647; schwannoma-derived growth factor; SDGF
Gene Symbols AREG
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human Amphiregulin. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 374
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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