Amphiregulin Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-5698	100 μL

Catalog No. 50-198-5698 Supplier Bioss Supplier No. BS3847R

Description

Rabbit Polyclonal Antibody

Amphiregulin (AR) binds to EGF-Receptor (EGFR) with lower affinity than EGF. The mature secreted form AR is an 84-amino acid residue glycosylated polypeptide growth regulator, which is generated by proteolytic processing of a 252-amino acid transmembrane precursor. Seven different polypeptide ligands, which derive from distinct genes, are capable of binding to the extracellular domain of EGFR. These ligands include EGF, TGFalpha, AR, HB-EGF, cripto-1, epiregulin, and betacellulin. All of these growth factors contain a characteristic EGF-like domain which is defined by 6 evenly spaced cysteine residues that generate 3 loops through the formation of disulfide bonds. AR protein has been localized by immunohistochemistry to the epithelium of the colon, stomach, pancreas, breast, and placenta. AR is reportedly overexpressed in human cancers of breast, colon, stomach, and pancreas.

Specifications

• Antigen: Amphiregulin
• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: AREG
• Gene Accession No.: P15514
• Gene Alias: Amphiregulin; amphiregulin B; AR; AREG; AREGB; Colorectum cell-derived growth factor; CRDGF; Mcub; MGC13647; Schwannoma-derived growth factor; SDGF
• Gene Symbols: AREG
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide derived from human Amphiregulin .
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 374
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG