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Amphiregulin Mouse anti-Human, Clone: AREG559, eBioscience™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  eBioscience 14537082

Catalog No. 14-537-082


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Description

Description

The AREG858 monoclonal antibody reacts with human Amphiregulin (AR). AR is a member of the Epidermal Growth Factor (EGF) family and is expressed as a transmembrane precursor protein and released by proteolytic cleavage. Soluble AR is a ligand for the EGF receptor (EGFR) and the interaction promotes growth of normal epithelial cells, fibroblasts and keratinocytes. In the context of the immune system AR functions as an effector molecule for tissue repair and homeostasis, mediates resistance and tolerance to infection, and suppresses inflammation. Under different disease and activating conditions AR is expressed in T cells, group 2 innate lymphoid cells, basophils, mast cells, eosinophils, and neutrophils. Applications Reported: This AREG559 antibody has been reported for use in flow cytometric analysis and western blot. Applications Tested: This AREG559 antibody has been tested by western blot analysis of stimulated normal human peripheral blood cells. This can be used 1-10 µg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Amphiregulin (AR) binds to EGF-Receptor (EGFR) with lower affinity than EGF. The mature secreted form AR is an 84-amino acid residue glycosylated polypeptide growth regulator, which is generated by proteolytic processing of a 252-amino acid transmembrane precursor. Seven different polypeptide ligands, which derive from distinct genes, are capable of binding to the extracellular domain of EGFR. These ligands include EGF, TGFalpha, AR, HB-EGF, cripto-1, epiregulin, and beta cellulin. All of these growth factors contain a characteristic EGF-like domain which is defined by six evenly spaced cysteine residues that generate three loops through the formation of disulfide bonds. AR protein has been localized by immunohistochemistry to the epithelium of the colon, stomach, pancreas, breast, and placenta. AR is reportedly overexpressed in human cancers of breast, colon, stomach, and pancreas.
Specifications

Specifications

Amphiregulin
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
P15514
Colorectum cell-derived growth factor, CRDGF, AREG, SDGF, Mcub, AREGB, MGC13647
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Flow Cytometry, Western Blot
AREG559
Unconjugated
AREG
Liquid
AREG
IgG1, kappa
100 μg
4° C, do not freeze
Primary
374
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