AMPK alpha 1 Rabbit anti-Bovine, Human, Rat, Polyclonal, Bethyl Laboratories

Rabbit Polyclonal Antibody

Supplier:  Bethyl Laboratories, Inc A300507A

Catalog No. 50-155-7783

Description

The recommended shelf life for this product is 1 year from date of receipt. Application Note: For IHC, epitope retrieval is not recommended. Based on 100% sequence identity, this antibody is predicted to react with Mouse and Orangutan

AMPKa belongs to the family of AMP activated protein kinases, that plays a central role in regulating cellular and organismal energy balance in response to the balance between AMP/ATP, and intracellular Ca2+ levels. AMPK exists as a heterotrimer comprising of catalytic alpha subunit, and regulatory beta and gamma subunits. The alpha subunit is activated by increases in the cellular AMP:ATP ratio caused by metabolic stresses, and can mediate the effects of the adipokines leptin and adiponectin. Two isoforms differ in subcellular localization and AMP-dependence. Phosphorylation of threonine 172 in the alpha subunit is a key determit of AMPK activity.

Specifications

• Antigen: AMPK alpha 1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PRKAA1
• Gene Alias: AMPK, AMPKa1, MGC33776, MGC57364
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 540404, 5562, 65248
• Content And Storage: 4° C
• Form: Liquid

• Applications: Immunohistochemistry, Immunoprecipitation, Western Blot
• Concentration: 1 mg/ml
• Formulation: phosphate, tris citrate with 0.09% sodium azide; pH 7-8
• Gene Accession No.: P54645, Q13131
• Gene Symbols: Prkaa1
• Immunogen: Between 350 and 400
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Bovine, Human, Rat
• Product Type: Antibody
• Isotype: IgG