Invitrogen™ AMPK gamma-1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA527471

Catalog No. PIPA527471

Description

Recommended positive controls: mouse liver. Predicted reactivity: Mouse (99%), Rat (98%), Zebrafish (88%), Xenopus laevis (80%), Pig (100%), Chicken (92%), Rhesus Monkey (100%), Bovine (100%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Specifications

• Antigen: AMPK gamma-1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PRKAG1
• Gene Alias: 5'-AMP-activated protein kinase subunit gamma-1; 5'-AMP-activated protein kinase, gamma-1 subunit; AA571379; AMP-activated protein kinase, noncatalytic gamma-1 subunit; ampk gamma; AMPK gamma1; AMPK gamma-1 chain; AMPK subunit gamma-1; AMPKG; BB036179; Prkaac; PRKAG1; Prkga1; Protein kinase AMP-activated gamma; protein kinase AMP-activated non-catalytic subunit gamma 1; protein kinase, AMP-activated, gamma 1 non-catalytic subunit
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 19082, 5571
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunoprecipitation, Western Blot
• Concentration: 0.33 mg/mL
• Formulation: 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: O54950, P54619
• Gene Symbols: PRKAG1
• Immunogen: Recombinant fragment corresponding to a region within amino acids 1 and 224 of Human AMPK gamma 1.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov