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  5. Tocris Bioscience™ AMZ 30

Tocris Bioscience™ AMZ 30
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Catalog No. 692350
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent, selective and irreversible protein phosphatase methylesterase-1 (PME-1) inhibitor

AMZ 30 is a potent, selective and irreversible inhibitor of protein phosphatase methylesterase-1 (PME-1; IC50 = 600 nM) with > 100-fold selectivity for PME-1 over other serine hydrolases in human cell lysates. AMZ 30 inactivates PME-1 and reduces the demethylated form of serine/threonine protein phosphatase 2A (PP2A) in HEK 293T cells. AMZ 30 perturbs leucine carboxyl methyltransferase-1 (LCMT1)-PME-1 methylation equilibrium leading to shortening of mitotic spindles and mitotic arrest in HeLa cells. It also shows antiproliferative properties in an in vitro model of endometrial carcinoma.

Specifications

Chemical Name or Material (2 E)-2-[(4-Fluorophenyl)sulfonyl]-3-[1-[(3-nitrophenyl)sulfonyl]-1 H-pyrrol-2-yl]-2-propenenitrile
CAS 1313613-09-0
Quantity 50 mg
Target Hydrolase Inhibitors
Molecular Formula C19H12FN3O6S2
Purity 0.98
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