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Tocris Bioscience™ ANA 12
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Catalog No. 478110
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50 mg
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47-811-0 10 mg
47-815-0 50 mg
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Description

TrkB receptor antagonist

TrkB receptor antagonist. Demonstrates a 2-site mode of action, preventing activation by BDNF non-competitively (IC50 values are 45.6 nM and 41.1 μM for the high and low affinity sites respectively). Displays no effect on TrkA and TrkC in an assay of neurite outgrowth. Demonstrates antidepressant properties. Also exhibits anti-seizure effects in an ischemia-induced neonatal seizure model by blocking down-regulation of KCC2.

Chemical Identifiers

CAS 219766-25-3
Molecular Formula C22H21N3O3S

Specifications

Quantity 10 mg
Formula Weight 407.49
Purity >99%
Molecular Weight (g/mol) 407.49
Chemical Name or Material ANA 12

Safety and Handling

Recommended Storage Store at +4°C
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