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ANA 12, Tocris Bioscience™ Available on GSA/VA Contract for Federal Government customers only.

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Quantity:
10mg
50mg
This item is not returnable. View return policy
219766-25-3
C22H21N3O3S
407.488
TUSCYCAIGRVBMD-UHFFFAOYSA-N
ana-12,ana 12,n-2-hexahydro-2-oxo-1h-azepin-3-yl amino carbonyl phenyl-benzo b thiophene-2-carboxamide,trkb antagonist,n-2-2-oxoazepan-3-yl carbamoyl phenyl-1-benzothiophene-2-carboxamide,maybridge1_001394,ana12,ana hplc,n-2-2-oxoazepan-3-yl carbamoyl phenyl benzo b thiophene-2-carboxamide
2799722
N-[2-[(2-oxoazepan-3-yl)carbamoyl]phenyl]-1-benzothiophene-2-carboxamide
C1CCNC(=O)C(C1)NC(=O)C2=CC=CC=C2NC(=O)C3=CC4=CC=CC=C4S3
This item is not returnable. View return policy
219766-25-3
C22H21N3O3S
407.488
TUSCYCAIGRVBMD-UHFFFAOYSA-N
ana-12,ana 12,n-2-hexahydro-2-oxo-1h-azepin-3-yl amino carbonyl phenyl-benzo b thiophene-2-carboxamide,trkb antagonist,n-2-2-oxoazepan-3-yl carbamoyl phenyl-1-benzothiophene-2-carboxamide,maybridge1_001394,ana12,ana hplc,n-2-2-oxoazepan-3-yl carbamoyl phenyl benzo b thiophene-2-carboxamide
2799722
N-[2-[(2-oxoazepan-3-yl)carbamoyl]phenyl]-1-benzothiophene-2-carboxamide
C1CCNC(=O)C(C1)NC(=O)C2=CC=CC=C2NC(=O)C3=CC4=CC=CC=C4S3

TrkB receptor antagonist

TrkB receptor antagonist. Demonstrates a 2-site mode of action, preventing activation by BDNF non-competitively (IC50 values are 45.6 nM and 41.1 μM for the high and low affinity sites respectively). Displays no effect on TrkA and TrkC in an assay of neurite outgrowth. Demonstrates antidepressant properties. Also exhibits anti-seizure effects in an ischemia-induced neonatal seizure model by blocking down-regulation of KCC2.

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Quantity 50mg
Formula Weight 407.49
Percent Purity >99%
Chemical Name or Material ANA 12

Recommended Storage : Store at +4°C